The Postgraduate Institute of Medicine is managed by the Board of Management which is the principal administrative and academic authority of the Institute. Present Board of Management members are as follows.
July/2021
| Professor Senaka Rajapakse | Director/PGIM |
| Professor Chandanie Wanigatunge | Deputy Director/PGIM |
| Professor S.D. Jayaratne | UGC Appointed Member (Chairperson) |
| Mr. T.B.M. Atapattu | Nominee of the Secretary/Education |
| Major General Dr. Sanjeewa Munasinghe | Secretary/Health |
| Ms. W.E. Godagama | Nominee of the Secretary/Finance |
| Dr. Asela Gunawardena | Director General of Health Services |
| Professor Vajira H.W. Dissanayake | Nominee/Faculty of Medicine, University of Colombo |
| Professor Vasanthi Pinto | Nominee/Faculty of Medicine, University of Peradeniya |
| Professor Vasantha Devasiri | Nominee/Faculty of Medicine, University of Ruhuna |
| Professor M.G. Sathiadas | Nominee/Faculty of Medicine, University of Jaffna |
| Professor A Pathirana | Nominee/Faculty of Medical Sciences, University of Sri Jayawardenapura |
| Professor S.J. De S. Hewavisenthi | Nominee/Faculty of Medicine, University of Kelaniya |
| Dr. A.N. Arulpragasam | Nominee/Faculty of Health Care Sciences, Eastern University of SL |
| Dr. Senaka Pilapitiya | Nominee/Faculty of Medical & Allied Sciences, Rajarata University of SL |
| Professor A.M. Attygalla | Nominee/Faculty of Dental Sciences, University of Peradeniya |
| Professor Jayantha Jayawardena | UGC Appointed Member |
| Professor Nandadeva Samarasekera | UGC Appointed Member |
| Dr. Harsha Cabral | UGC Appointed Member |
| Professor Lakshman Ratnayake | UGC Appointed Member |
| Professor Arjuna de Silva | UGC Appointed Member |
| Mr. Rajan Asirwatham | UGC Appointed Member |
| Rev. Father Ivan Perera | Council nominee |
| Professor S Karunaratne | Council nominee |
| Co-opted Members | |
| Dr. Ranjan Dias | Chairperson/AAAEC |